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Proceedings of the National Academy of Sciences of the United States of America
  • Denis Maag, Thilo Mast, Marcus Elstner, Qiang Cui, Tomaš Kubař tarafından
    Extensive classical and quantum mechanical/molecular mechanical (QM/MM) molecular dynamics simulations are used to establish the structural features of the O state in bacteriorhodopsin (bR) and its conversion back to the bR ground state. The computed free energy surface is consistent with available experimental data for the kinetics and thermodynamics of…
  • Romain Schellenberger, Jerome Crouzet, Arvin Nickzad, Lin–Jie Shu, Alexander Kutschera, Tim Gerster, Nicolas Borie, Corinna Dawid, Maude Cloutier, Sandra Villaume, Sandrine Dhondt–Cordelier, Jane Hubert, Sylvain Cordelier, Florence Mazeyrat–Gourbeyre, Christian Schmid, Marc Ongena, Jean–Hugues Renault, Arnaud Haudrechy, Thomas Hofmann, Fabienne Baillieul, Christophe Clement, Cyril Zipfel, Charles Gauthier, Eric Deziel, Stefanie Ranf, Stephan Dorey tarafından
    Plant innate immunity is activated upon perception of invasion pattern molecules by plant cell-surface immune receptors. Several bacteria of the genera Pseudomonas and Burkholderia produce rhamnolipids (RLs) from l-rhamnose and (R)-3-hydroxyalkanoate precursors (HAAs). RL and HAA secretion is required to modulate bacterial surface motility, biofilm development, and thus successful colonization…
  • Yonatan Vanunu, Jared M. Hotaling, Mike E. Le Pelley, Ben R. Newell tarafından
    We examine how bottom-up (or stimulus-driven) and top-down (or goal-driven) processes govern the distribution of attention in risky choice. In three experiments, participants chose between a certain payoff and the chance of receiving a payoff drawn randomly from an array of eight numbers. We tested the hypothesis that initial attention…
  • Laura Rossmann, Katrin Bagola, Tharshana Stephen, Anna–Lisa Gerards, Bianca Walber, Anȷa Ullrich, Stefan Schulke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David–Watine, Spencer L. Shorte, Max Bastian, Ger van Zandbergen tarafından
    The COVID-19 pandemic highlights the importance of efficient and safe vaccine development. Vaccine adjuvants are essential to boost and tailor the immune response to the corresponding pathogen. To allow for an educated selection, we assessed the effect of different adjuvants on human monocyte-derived dendritic cells (DCs) and their ability to…
  • Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne D. Bindels, Rebecca Mastey, Jennifer Okalova, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil J. Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin tarafından
    Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the UPR regulator Activating Transcription Factor 6 (ATF6) cause severe congenital vision loss diseases such as achromatopsia by unclear pathomechanisms. To investigate this, we generated retinal organoids from achromatopsia patient…
  • Odo Diekmann, Hans G. Othmer, Robert Planque, Martin C. J. Bootsma tarafından
    The COVID-19 pandemic has led to numerous mathematical models for the spread of infection, the majority of which are large compartmental models that implicitly constrain the generation-time distribution. On the other hand, the continuous-time Kermack–McKendrick epidemic model of 1927 (KM27) allows an arbitrary generation-time distribution, but it suffers from the…
  • Kazusa Beppu, Ziane Izri, Tasuku Sato, Yoko Yamanishi, Yutaka Sumino, Yusuke T. Maeda tarafından
    Bacterial suspensions show turbulence-like spatiotemporal dynamics and vortices moving irregularly inside the suspensions. Understanding these ordered vortices is an ongoing challenge in active matter physics, and their application to the control of autonomous material transport will provide significant development in microfluidics. Despite the extensive studies, one of the key aspects…
  • Michael E. Mann tarafından
    More than two decades ago, my coauthors, Raymond Bradley and Malcolm Hughes, and I published the now iconic “hockey stick” curve. It was a simple graph, derived from large-scale networks of diverse climate proxy (“multiproxy”) data such as tree rings, ice cores, corals, and lake sediments, that captured the unprecedented…
  • Dimitrios Gkikas, Dimitris Stellas, Alexia Polissidis, Theodora Manolakou, Maroula G. Kokotou, George Kokotos, Panagiotis K. Politis tarafından
    Nervous system malignancies are characterized by rapid progression and poor survival rates. These clinical observations underscore the need for novel therapeutic insights and pharmacological targets. To this end, here, we identify the orphan nuclear receptor NR5A2/LRH1 as a negative regulator of cancer cell proliferation and promising pharmacological target for nervous…
  • Chengjin Ye, Kevin Chiem, Jun-Gyu Park, Jesus A. Silvas, Desarey Morales Vasquez, Julien Sourimant, Michelle J. Lin, Alexander L. Greninger, Richard K. Plemper, Jordi B. Torrelles, James J. Kobie, Mark R. Walter, Juan Carlos de la Torre, Luis Martinez-Sobrido tarafından
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, is one of the biggest threats to public health. However, the dynamic of SARS-CoV-2 infection remains poorly understood. Replication-competent recombinant viruses expressing reporter genes provide valuable tools to investigate viral infection. Low levels of reporter…